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- W2387884647 abstract "Objective: To establish a HPLC method for determining the concentration of nizatidine in human plasma. Methods: The proteins were precipitated by adding methanol in the plasma samples, the supernatant was injected directly into the system. The analytical column was Nucleosil 100-5 (4. 6 mm×250 mm,5 μm),the mobile phase was acetonitrile: methanol:water:ammonia water (1000:200:25:1.25,pH 7.0),the flow rate was 1. 0 mL/min,the detection wavelength was 824 nm. Results: The linear range of nizatidine of the method was 15. 625-2 000 ng/mL (r=0. 999 9), the inter-and intra-day RSD were lower than 1. 2%. Conclusion: The method is simple, rapid, accurate, sensitive and economic. It can be used for studying pharmacokinetics of nizatidine in human body." @default.
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- W2387884647 date "2005-01-01" @default.
- W2387884647 modified "2023-09-25" @default.
- W2387884647 title "Determination of concentration of nizatidine in human plasma using HPLC method" @default.
- W2387884647 hasPublicationYear "2005" @default.
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