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- W2387897807 abstract "Objective To review the lipid-lowering effect and safety of ezetimibe combining simvatatin therapy. Methods The databases of Cochrane Library, PubMed, Embase, WangFang Database, CNKI, CBM and VIP Database were retrieved with computers for collecting randomized controlled trials (RCT) about ezetimibe combining simvatatin in lipid-lowering treatment until Sept. 30, 2012. All literature was read and selected by two researchers independently according to inclusion and exclusion criterions, and materials were extracted, checked crossly and given methodological quality evaluation. The Meta-analysis was conducted by using RevMan 5.2 software. Results There were totally 10 RCT included involving 3367 cases, and the results of Meta-analysis showed that ezetimibe combining simvatatin therapy decreased significantly the levels of plasma low-density lipoprotein-cholesterol (LDL-C, SMD=-0.87, 95% CI:-1.10--0.64, P0.001) , total cholesterol (TC,SMD=-0.81, 95% CI:-1.03- -0.59, P0.001 ) and triglyceride (TG, SMD=-0.41, 95% CI:-0.66- -0.17, P0.05) , and increased significantly the level of high-density lipoprotein-cholesterol (HDL-C, SMD=0.15, 95% CI:0.04-0.26, P0.05) compared with simvatatin monotherapy. The increase of transaminase and creatine kinase and incidence of adverse events induced by ezetimibe combining simvatatin therapy had no statistical significance compared with simvatatin monotherapy. Conclusion Zetimibe combining simvatatin therapy can reduce the level of blood fat with higher safety and tolerance compared with simvatatin monotherapy, while more multiple-center and large-sample RCT with higher quality are required for further identifying the results." @default.
- W2387897807 created "2016-06-24" @default.
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- W2387897807 date "2013-01-01" @default.
- W2387897807 modified "2023-09-24" @default.
- W2387897807 title "A Meta-analysis on lipid-lowering effect and safety of ezetimibe combining simvatatin therapy" @default.
- W2387897807 hasPublicationYear "2013" @default.
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