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- W2387914515 abstract "Objective To evaluate the diagnostic accuracy of serum soluble mesothelin related proteins(SMRP)in patients with ovarian cancer.Methods Serum SMRP level in 63 patients with ovarian cancer,85 patients with gynecological benign disease and 51 healthy individuals was detected by ELISA.The diagnostic performance of SMRP and CA125 were evaluated and compared by receiver operating characteristic(ROC)curve analysis.The diagnostic value of combined using SMRP and CA125 was also investigated by parallel and series test based on the optimal threshold derived from ROC curve.Results Increased serum SMRP concentration,which was positively correlated with FIGO stages,was observed in patients with ovarian cancer,when compared with patients with gynecological benign disease and healthy individuals.The area under curve(AUC)of SMRP was comparable with CA125(0.77vs 0.81,P=0.46 for comparison).At the threshold of 1.67nmol/L(the optimal threshold with highest Youden index),the diagnostic sensitivity(95% confidence interval,95%CI)and specificity(95%CI)of SMRP was 0.82(0.73-0.90)and 0.66(0.54-0.78),respectively.Further more,in series test based on SMRP and CA125,the diagnostic specificity increased to 0.96,while sensitivity decreased to 0.67.By contrast,the diagnostic specificity decreased to 0.48 and sensitivity increased to 0.97 in parallel test.Conclusion Serum SMRP was a promising diagnostic biomarker,as well as a potential prognosis factor for ovarian cancer.Combined use of serum SMRP and CA125 could improve the diagnostic accuracy of ovarian cancer." @default.
- W2387914515 created "2016-06-24" @default.
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- W2387914515 date "2014-01-01" @default.
- W2387914515 modified "2023-09-23" @default.
- W2387914515 title "Serum soluble mesothelin related proteins detection in patients with ovarian cancer and its clinical indications" @default.
- W2387914515 hasPublicationYear "2014" @default.
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