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- W2387918560 abstract "[Purpose] To investigate the expression of matrix metalloproteinase-9(MMP-9) gene in the peripheral blood of patients with esophageal squamous cell cancer(ESCC) and its relationships with clinicopathologic characteristics and survival.[Methods] The expression of MMP-9 mRNA from peripheral blood samples of ESCC was detected by real-time qPCR,and the relationships of MMP-9 expression with clinicopathologic characteristics and prognosis were analyzed.[Results] The positive expression rate of MMP-9 in the peripheral blood of patients with ESCC was 62.7%(106/169),which positively correlated with the lymph node metastasis(P=0.039),distant metastasis(P=0.019) and TNM stage(P=0.014)。Univariate analysis showed that N stage(P=0.000),M stage(P=0.002),TNM stage(P=0.003) and MMP-9 expression(P=0.042) had significant impact on patients' survival.The survival of ESCC patients with positive expression of MMP-9 was lower than that of patients with negative expression of MMP-9.Multivariate analysis showed that N stage was an independent impact factor for prognosis(RR=1.671,95%CI:1.212～2.306).[Conclusion] The high expression of MMP-9 correlates with the metastasis of esophageal cancer and might indicate poor prognosis." @default.
- W2387918560 created "2016-06-24" @default.
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- W2387918560 date "2013-01-01" @default.
- W2387918560 modified "2023-09-27" @default.
- W2387918560 title "Expression of Matrix Metalloproteinase-9(MMP-9) mRNA in the Peripheral Blood of Patients with Esophageal Squamous Cell Cancer and Its Clinical Significance" @default.
- W2387918560 hasPublicationYear "2013" @default.
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