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- W2387928103 abstract "Objective:To study the clinicopathologic significance of microvessel density (MVD) and the expression of vascular endothelial growth factor(VEGF) in human giant cell tumor of bone(GCT).Methods:VEF protein and CD34 expressions in 40 cases of human GCT were determined by immunohistochemical staining.The relationship of VEGF and MVD with the clinicopathologic features of GCT were analysed .Results:VEGF and CD34 were expressed in all cases of GCT investigated.VEGF was presented in spindle shaped stromal like tumor cells and osteoclast like multinucleate giant cells.The levels of VEGF protein expression were higher in stage Ⅲ GCT than in stage Ⅰ/Ⅱ GCT(Ennekings clinical stage of GCT).CD34 expression levels showed difference in 40 cases of GCT with the higher stage Ⅰ/Ⅱ GCT (Jaffe pathological grade),MVD showed significant difference between stage Ⅰ/Ⅱ and stage Ⅲ of GCT( P 0.01),but no significant difference between grade Ⅰ/Ⅱ and grade Ⅲ GCT( P 0.05).The VEGF expression was positively correlated with the MVD value.Conclusion MVD and expression of VEGF were remarkably related to clinical stage,but not related to pathologic grade of GCT.MVD and VEGF may be used as one of the indicators for the prognosis of GCT." @default.
- W2387928103 created "2016-06-24" @default.
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- W2387928103 date "2001-01-01" @default.
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- W2387928103 title "Clinicopathologic Study of Vascular Endothelial Growth Factor and Angiogenesis in Human Giant Cell Tumor of Bone" @default.
- W2387928103 hasPublicationYear "2001" @default.
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