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- W2387930519 abstract "Objective: To investigate the changes and clinical significance of inflammatory cytokines in saliva and peripheral blood of the patients with nasopharyngeal carcinoma undergoing radical radiotherapy. Methods: Forty patients with nasopharyngeal carcinoma, who underwent radical radiotherapy, were included in this study. The levels of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-6 and IL-10 in saliva and peripheral blood were detected in patients with three doses of radiotherapy including DT=0 Gy, DT=40 Gy and DT= 70 Gy. Results: (1) The levels of six cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-6 and IL-10) were significantly higher in saliva than those in peripheral blood (P 0.01) at three doses of radiotherapy. (2) The levels of six cytokines were significantly increased in both saliva and peripheral blood at DT=40 Gy compared with those at DT=0 Gy (P 0.01). (3) The level of IL-10 increased in saliva and peripheral blood at DT=70 Gy (P 0.01), whereas levels of IFN-γ, TNF-α, IL-2 and IL-6 decreased compared with those at DT=0 Gy (P 0.01). The level of IL-4 in saliva was lower at DT=70 Gy than that at DT=0 Gy (P 0.001). There was no significant difference in the blood level of IL-4 between DT=70 Gy and DT=0 Gy (P 0.05). Conclusion: Inflammatory factors played an important role in the occurrence and development process of nasopharyngeal radical radiotherapy in patients with acute radiation stomatitis. Changes of cytokine similar to that of salivavy." @default.
- W2387930519 created "2016-06-24" @default.
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- W2387930519 date "2012-01-01" @default.
- W2387930519 modified "2023-09-24" @default.
- W2387930519 title "The Changes and Clinical Significance of Inflammatory Cytokines in Saliva and Peripheral Blood of Patients with Acute Radiation-Induced Stomatitis" @default.
- W2387930519 hasPublicationYear "2012" @default.
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