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- W2387934905 abstract "Objective To observe the effect of matrine on telomerase activity apoptosis of bone marrow cells in humans exposure to 192 Ir low-dose radiation.Methods Extent of bone marrow cell proliferation were observed by smears;Telomerase activity of bone marrow cell were detected by TRAP-ELISA(telomerie repeat amplification protocol-Enzyme linked immunosorbent assay).Apoptosis rate were detected by flow cytometry(FCM) after marked with Annexin V-FITC and PI.A study was carried out on effects of matrine,fu fang zao fan pills,and placebo as treatments,and observe the proliferation,telomerase activity and apoptosis of bone marrow cells in humans exposure to 192 Ir low-dose radiation(54 men,0.05 ～ 0.66 Gy).Results Cell morphous of all lines were abnormal in irradiated people,The total abnormal rate is up to 20.4% including hypoplasia and polarhypoplasia;The telomerase activity of bone marrow cell was obviously higher than normal with the time go in irradiated group,The apoptosis rate of irradiated group was degrade with the time go;Cell morphous of all lines was gradually up to normal by treat with matrine and fu fang zao fan pills,so as the telomerase activity,and the apoptosis rate wasincreased,the effect of matrine treatment group was significantly better than others(P 0.01).Conclusion As a protective agent from irradiation,matrine could surppress telomerase activity in men irradiated by 192 Ir,and induce apoptosis of bone marrow." @default.
- W2387934905 created "2016-06-24" @default.
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- W2387934905 date "2011-01-01" @default.
- W2387934905 modified "2023-09-23" @default.
- W2387934905 title "Effect of matrine on telomerase activity and apoptosis of bone marrow cells in humans exposure to ~(192)Ir low-dose radiation" @default.
- W2387934905 hasPublicationYear "2011" @default.
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