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- W2387940722 abstract "Objective Mesoporous silica nanomaterials( MSNs) plays a very important role in biomedical fields,its physicochemical properties such as dispersion can affect the cellular uptake rate,and maybe cause cell apoptosis. The aim of this study is to explain the apoptosis effect induced by MSNs with diverse dispersion in 293T cells in vitro. Methods Two MSNs named MSN-1 and MSN-2 with different dispersion were prepared; Transmission electron microscopy was used to observe the phagocytosis of 293T cells caused by the two MSNs; 293T cells were exposed to 0 μg / mL,100 μg / mL,150 μg / mL,200 μg / mL and 250 μg / mL of MSNs in vitro for 24 h,and measured the apoptosis by flow cytometer. Results The dispersion of MSN-2 was better than MSN-1; about 10% MSNs were phagocyted by 293T cells; MSN-1 incubated with 293T cells induced obvious apoptosis effect( P 0. 05),while MSN-2 not. Conclusion MSN-2 with satisfactory dispersion was stable and safe in 293T cells in certain dose." @default.
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- W2387940722 date "2014-01-01" @default.
- W2387940722 modified "2023-09-24" @default.
- W2387940722 title "Effect on apoptosis of 293T cells induced by mesoporous silica nanomaterials with different dispersion" @default.
- W2387940722 hasPublicationYear "2014" @default.
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