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- W2387942329 abstract "OBJECTIVE:To prepare Acetaminophen multilayer microcapsules and to investigate drug release property and mechanism of it.METHODS:Drug-loading(acetaminophen) multilayer(acacia-chitosan-acacia-chitosan) microcapsules were prepared by solution drying method(complex emulsion method) using chitosan and acacia as coating materials and glutaraldehyde as crosslinking agent.The preparation technology was optimized by orthogonal test with volume ratio of acacia solution to dichloromethane(A),amount of chitosan(B),ratio of glutaraldehyde volume to total mass of coating material as factors and encapsulation efficiency as index.Drug release kinetic model was fitted and drug release mechanism was discussed by determining accumulative drug release rate in HCl solution.RESULTS:The optimal preparation process was A 4:3,B 0.6 g and C 1:3.Prepared multilayer microcapsules were round completely and smooth with thick capsule wall.Significant burst effect was not found.The multilayer microcapsules released in 12 h completely,which followed Ritger-Peppas model.CONCLUSION:Prepared drug-loading multilayer microcapsules demonstrate lower burst release and longer drug delivery." @default.
- W2387942329 created "2016-06-24" @default.
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- W2387942329 date "2012-01-01" @default.
- W2387942329 modified "2023-09-23" @default.
- W2387942329 title "Study on Preparation and in Vitro Drug Release of Acetaminophen/Acacia-chitosan Multilayer Microcapsule" @default.
- W2387942329 hasPublicationYear "2012" @default.
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