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- W2387992418 abstract "Aims: To observe the morphological changes of corpus striatum neurons and the function of nitric oxide (NO) in hepatic cirrhosis and hepatic encephalopathy by variance of neurons and nitric oxide synthase (NOS) in corpus striatum of hepatic cirrhosis rats. Methods: Liver cirrhosis model was made by CCl4. The neurons were stained by Nissl's staining method. The change of NOS positive neurons was observed by nicotinamide adenine dinucleotide-diaphorase (NADPH-d) staining method. The optical density and number of neurons, the change of expression and quantity of NOS positive neurons were studied by image analysis and quantitative analysis. Results: Liver cirrhosis models were successfully constructed. The color of neurons thinned (0.67±0.04 vs 0.78±0.06) and the number also decreased (12.0±3.1 vs 19.7±5.4), whereas the expression and quantity of NOS positive neurons increased manifold (gray scale: 148.0±12.1 vs 172.0±10.7, number: 14.80±2.59 vs 8.96±1.71) in corpus striatum of cirrhotic rats. Conclusions: The decrease of neurons and Nissl's body may be one of the histologic basis of emergence of hepatic encephalopathy, and NO may participate in neuronal damage and in pathogenesis of hepatic cirrhosis and hepatic encephalopathy." @default.
- W2387992418 created "2016-06-24" @default.
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- W2387992418 date "2002-01-01" @default.
- W2387992418 modified "2023-09-23" @default.
- W2387992418 title "The Quantitative Research of Neurons and Nitric Oxide Synthase in Corpus Striatum of Experimental Hepatic Cirrhosis Rats" @default.
- W2387992418 hasPublicationYear "2002" @default.
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