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- W2387992456 abstract "Objective To investigate the damage effect of high-dose Vitamin C(VC)on calf thymus DNA and the protective effect of sodium quercetin-7-sulfonate.Methods Calf thymus DNA incubated with VC(0.1,0.25,0.50 mmol/L;quercetin and sodium quercetin-7-sulfonate were pretreated or co-treated with VC(0.50 mmol/L) in calf thymus DNA.The changes of DNA were analyzed by agrose gel electrophoresis and spectrophotometry.Results The DNA ladder and DNA concentration had no obvious changing in 0.10 mmol/L VC group,but DNA ladder disappeared and the concentration of DNA obviously increased in 0.25 and 0.50 mmol/L VC groups.Pretreatment or co-treatment with quercetin or sodium quercetin-7-sulfonate,the DNA ladder appeared more clearly and the concentration of DNA decreased obviously.Conclusions These suggest that high-dose VC could induce calf thymus DNA damage and sodium quercetin-7-sulfonate has protective effect on high-dose VC induced DNA damage." @default.
- W2387992456 created "2016-06-24" @default.
- W2387992456 creator A5057568812 @default.
- W2387992456 date "2012-01-01" @default.
- W2387992456 modified "2023-09-26" @default.
- W2387992456 title "Protective Effect of Sodium Quercetin-7-mono-sulfonate on High-dose Vitamin C Induced DNA Damage" @default.
- W2387992456 hasPublicationYear "2012" @default.
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