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- W2387996943 abstract "Objective To study the diagnostic value of cancer antigen 125(CA125) ,cancer antigen 19-9(CA19-9) ,carcinoembryonic antigen(CEA) ,squamous cell carcinoma antigen(SCC) ,neuron-specific enolase(NSE) ,cytokeratin 19 fragments(CYFRA21-1) of pleural effusion and serum and exfoliative cytological examination of pleural effusion for differentiating benign and malignant lung diseases.Methods Pleural effusion or serum concentrations of CA125,CA19-9,CEA,SCC,NSE,CYFRA21-1 were measured by chemiluminescence immunoassay(CLIA) and electro-chemiluminescence immunoassay(ECLIA) in 26 patients with malignant lung diseases,41 patients with benign lung diseases and 30 healthy individuals.Exfoliative cytological examination was done in pleural effusion as well.The optimum cut-off points resulting from the best sensitivity-specificity balance in the ROC curves were constructed.Results CEA of pleural effusion and CYFRA21-1 of serum had the largest area under the ROC curve in the group of patients with lung cancer.The pleural effusion and serum(P/S) ratio of CEA had larger area under the ROC curve than that of the other 5 tumor markers.Exfoliative cytological examination of pleural effusion in patients with malignant and benign lung diseases showed sensitivity of 69.23% and specificity of 100%,and in combination with CEA of pleural effusion showed 100% and 97.56% respectively.Conclusions Detecting the concentrations of CEA,CYFRA21-1 of pleural effusion and serum is helpful to differentiating benign and malignant lung diseases.Combined detection of CEA and exfoliative cytological examination in pleural effusion could greatly improve the diagnostic sensitivity for lung cancer." @default.
- W2387996943 created "2016-06-24" @default.
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- W2387996943 date "2007-01-01" @default.
- W2387996943 modified "2023-09-26" @default.
- W2387996943 title "Clinical value of tumor markers in differentiating benign and malignant lung diseases with pleural effusion" @default.
- W2387996943 hasPublicationYear "2007" @default.
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