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- W2387997988 abstract "Objective: To investigate the regulation of ligustrazin on expression of B7-1(CD80)and B7-2 (CD86)mRNA in peripheral blood mononuclear cells (PBMC) from active stage lupus nephritis (LN), so as to obtain some principle evidences of ligustrazin treatment. Methods: PBMCs from active stage LN were cultivated and treated with PBS, ligustrazin, dexamethasone and ligustrazin plus dexamethasone injection respectively for 3 days. After cultivation, B7-1(CD80)and B7-2 (CD86)mRNA expressions were measured by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). Results: Compared with PBS control group, both Ligustrazin and dexamethasone injection group check the expressions of B7-2 mRNA (P0.05) and is more significant in Ligustrazin plus dexamethasone injection group. All group could not inhabit the expressions of B7-1 mRNA(P0.05) Conclusion: Ligustrazin suppressed may significantly down-regulate expression of B7-2 mRNA in active stage LN and have synergetic effect with dexamethasone injection" @default.
- W2387997988 created "2016-06-24" @default.
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- W2387997988 date "2001-01-01" @default.
- W2387997988 modified "2023-09-23" @default.
- W2387997988 title "Influence of ligustrazin injection on the expression of B7-1and B7-2 mRNA of peripheral blood mononuclear cells (PBMC) from active stage lupus nephritis" @default.
- W2387997988 hasPublicationYear "2001" @default.
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