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- W2388001483 abstract "Objective To evaluate systematically the effectiveness of warfarin in prevention of catheter-related thrombosis(CRT) in cancer patients to provide corresponding evidence for CRT prevention.Methods Literatures of randomized controlled trials were collected by retrieving PUBMED/MEDLINE、OVID、EBSCO、EMBASE、CBM、CNKI,supplemented by citation and manual searches.The screened literature,extracted data and quality assessment done independently by 2 researchers were analyzed by RevMan5.0 statistical software using Meta-analysis.Results A total of 6 screened literatures of randomized controlled trials were analyzed by Meta-analysis and 1 522 cancer patients were found.There was significant difference in CRT incidence rate between groups oral warfarin and placebo [RR=0.68,95%CI(0.52,0.89),P=0.004],but no difference was noted in bleeding incidence or mortality(P=0.98).Conclusion Oral warfarin can reduce effectively CRT incidence in cancer patients,not increasing bleeding incidence and mortality.Because of fewer studies on it,more large samples of rigorously-designed randomized controlled trials are demanded for further evidences." @default.
- W2388001483 created "2016-06-24" @default.
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- W2388001483 date "2011-01-01" @default.
- W2388001483 modified "2023-09-26" @default.
- W2388001483 title "Oral Warfarin in Prevention of Catheter-related Thrombosis in Cancer Patients:A Systematic Review" @default.
- W2388001483 hasPublicationYear "2011" @default.
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