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- W2388004967 abstract "Objective To explore the changes of high-sensitivity C reactive protein(hs-CRP) and platelet parameter levels in newborns with hypoxic-ischemic encephalopathy(HIE)and its clinical significance.Methods Thirty-five infants with HIE and 16 healthy newborns were selected as study cases and controls respectively by automantc biochemistry analyzer.Serum hs-CRP content was measured by reaction rate method;Platelet parameter levels were detected by collecting blood samples from peripheral vascular of heel,and the activity of creatine kinase(CK),creatine phosphokinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),alpha-hydroxybntyric dehydrogenase(α-HBDH),alanine transaminase(ALT),aspartate aminotransferase(AST) were assayed as well.Results 1.The hs-CRP levels in newborns with HIE increased obviously in acute stage,and significant difference were observed compared with controls(P0.05);The hs-CRP concentration decreased obviously during convalescence without significant differences compared with that of control group(P0.05).2.PLT in newborns with HIE decreased significantly in acute stage compared with that of controls(P0.01),while mean platelet volume(MPV) and platelet distribution width(PDW) increased significantly(P0.01).No significant difference was observed in PLT,MPV,PDW during convalescence between cases and controls(P0.05).3.The values of CK,CK-MB,LDH,α-HBDH,AST,ALT in newborns with HIE were significantly higher than those in controls in acute stage(P0.01,0.05),and these values remarkedly higher during convalescence than those in controls,although values of CK,CK-MB,α-HBDH and ALT decreased significantly(P0.01,0.05).Conclusions The variation of hs-CRP and platelet parameter levels in newborns with HIE are paralled to the course of disease,which can sensitively reflect the state and trajectory of HIE.Therefore,hs-CRP and platelet parameter may be used as vital indices for evaluating curative effect and judging state of HIE." @default.
- W2388004967 created "2016-06-24" @default.
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- W2388004967 date "2006-01-01" @default.
- W2388004967 modified "2023-09-24" @default.
- W2388004967 title "Changes and Significance of Serum High-Sensitivity C Reactive Protein and Platelet Parameter Levels in Newborns with Hypoxic-Ischemic Encephalopathy" @default.
- W2388004967 hasPublicationYear "2006" @default.
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