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- W2388007017 abstract "Objective:To explore the risk factors of P16 protein abnormal expression in colorectal cancer(CRC).Methods:Big four hospitals' CRC patients in Shanxi province were chosen as sample cases.The tumor tissues were detected by s-p immunohistochemistry.The correspond patients wrere divided into P16 abnormal expression positive group and negative group.The case-case study and SAS software were used for factor analysis.Results:The P16 abnormal expression,that is the inactivation of P16 gene expression rate was 51.8%(57/110),it is positive group.There are two factors associated with P16 abnormal expression by using single factor analysis.They are follows:eat fat meat(OR=2.0481),family carcinoma history(OR=13.8092);The stepwise logistic regression analysis shows that the years of smoking(OR=1.060),eat fat meat(OR=3.536),family carcinoma history(OR=37.0815) are the dangerous factors.Then we analysed the dose-response relatonship of the years of smoking and the number of family carcinoma history person with P16 abnormal expression respectively.The results shows that the number of family carcinoma person and P16 abmormal expression has significance.The years of smoking has no significance,but the OR value of over forty years is far higer than the low years.Conclusions:In the study,we can conclude that the years of smoking,eat fat meat and family carcinoma history are the risk factors of P16 abnormal expression in CRC." @default.
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- W2388007017 date "2004-01-01" @default.
- W2388007017 modified "2023-09-23" @default.
- W2388007017 title "A STUDY ON RISK FACTORS OF P16 ABNORMAL EXPRESSION OF COLORECTAL CANCER." @default.
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