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- W2388012177 abstract "Objective:To assess the effects of recombinant human brain natriuretic peptide (rh- BNP) on circulatory and respiratory system in rats and nervous system in mice.Methods:Rats were ran- domly i.v.injected with one of four single doses of rhBNP 0,22.5,45.0 and 90.0μg·kg~(-1).The BP, ECG,respiratory rate,rhythm of the rats were observed pre-and post-injection.Mice were randomly i.v.injected with a single dose of rhBNP at either 0,45.0,90.0 or 180.0μg·kg~(-1) dose.The spontane- ous activities and climbing ability of the mice were assessed pre-and post-injection.Results:The rhBNP reduced systolic and diastolic pressure and mean arterial pressure of the rats in a dose-dependent manner. The reductions returned to normal within 2 hours after the injection.No significant changes in heart rate, cardiac rhythm,ECG (QRS interval,T wave,ST segment),respiratory rate,rhythm and magnitude of rats were found.The spontaneous activities and climbing ability of mice showed no impacts.Conclusion: The rhBNP moderately impacted the cardiovascular system of rats." @default.
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- W2388012177 date "2006-01-01" @default.
- W2388012177 modified "2023-09-28" @default.
- W2388012177 title "Safety pharmacology study of recombinant hmnan brain natriuretic peptide" @default.
- W2388012177 hasPublicationYear "2006" @default.
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