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- W2388048105 abstract "Objective To investigate the role of NADPH oxidase in oxidative stress involved in rabbit model atherosclerosis.Methods Twenty New Zealand rabbits were randomized into two groups and received restricted either stardard or cholesterol enriched diet but free water supply;and were individually housed in metal cages in an air-conditioned room for 10 weeks.Blood samples were drawn from ear edge vein of rabbits just one day before the experiment and at the 4th,8th,and 10th weekend after a fast of 8 hours,and their total cholesterol(TC),triglyceride(TG)and maleic dialdehyde(MDA)were assessed enzymatically.RT-PCR was used to measured the mRNA expression of NADPH oxidase subunit NOX2 and p22phox.The data were statistically analyzed by SPSS 10.0 software.Results The cholesterol enriched diet group had higher TG,TC and MDA levels as compared with the control group.The mRNA expression of NOX2 in the cholesterol group was significantly higher than that in the control group,whereas there was no significant difference in the mRNA expression of p22phox between the control group and the cholesterol enriched diet group.Conclusion The results suggest that the cholesterol enriched diet atherosclerosis model group shows increased lipid profiles and attenuated antioxidantive activity as compared with the control group,and the NADPH oxidase subunit NOX2 over expression is related with the oxidative stress status of rabbit model of atherosclerosis." @default.
- W2388048105 created "2016-06-24" @default.
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- W2388048105 date "2007-01-01" @default.
- W2388048105 modified "2023-09-24" @default.
- W2388048105 title "Role of NADPH Oxidase in Oxidative Stress Involved in Rabbit Atherosclerosis" @default.
- W2388048105 hasPublicationYear "2007" @default.
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