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- W2388049462 abstract "Objective To explore the effects of helicobacter pylori(H.pylori) and aspirin on the ulcer healing.Methods The gastric ulcers were induced with acetic acid in rats and then the rats were divided into 4 groups.The intragastric administration was made twice a day from day 12 to day 19 after ulcer induction:group A(0.9% sodium chloride injection + 0.9% sodium chloride injection),group B(H.pylori suspensions + 0.9% sodium chloride injection),group C(aspirin + 0.9% sodium chloride injection) and group D(H.pylori suspensions + aspirin).The expressions of epidermal growth factor(EGF) and vascular endothelial growth factor(VEGF) in gastric mucosa were observed through immunohistochemical method.The ulcer appearance,the thickness of regenerative mucosa and the number of dilated gland in the regenerative mucosa were observed through histological method on day 20 after ulcer induction.Results The ulcer area,the expression of EGF and VEGF,the thickness of regenerative mucosa and the number of dilated gland in the regenerative mucosa had statistical differences among group A,B,C and D(P0.01).The expression of EGF and VEGF in the regenerative mucosa were decreasing by order of A,B,C and D.The ulcer area was increasing by order of A,B,C and D.The thickness of the regenerative mucosa was decreasing by order of A,B,D and C.The number of dilated gland was increasing by order of A,C,D,and B group(P0.05).Conclusion H.pylori and aspirin could inhibit ulcer healing by inhibiting the expressions of EGF and VEGF.H.pylori and aspirin have synergetic effects." @default.
- W2388049462 created "2016-06-24" @default.
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- W2388049462 date "2011-01-01" @default.
- W2388049462 modified "2023-09-25" @default.
- W2388049462 title "Effects of Helicobacter Pylori and Aspirin on the Ulcer Healing" @default.
- W2388049462 hasPublicationYear "2011" @default.
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