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- W2388055878 abstract "Objective To observe the influence of transient high IOP by negative pressure suction during LASIK on BDNF and TrkB concentration in rabbit retina,and analyze the mechanism of RGCs apoptosis that caused by transient high IOP during LASIK.Methods 48 New Zealand white rabbits were randomized to experimental control,negative pressure suction 20 s,negative pressure suction 45 s and suction 3 min groups.The experimental control was treated only by laser.Rabbit eyes received suction for different periods of time(20 s,45 s,3 min) by negative pressure generator in different groups.Then the rabbit were executed at different time points of post-LASIK,such as postoperative instant,7 d,10 d,14 d,finally,retinal tissue was extracted to detect the concentration of BDNF and TrkB.Results The concentration of BDNF and TrkB dynamic observation:there were no statistical significance on concentration of BDNF and TrkB in negative pressure suction 20 s and 45 s groups compared with experimental control(P 0.05).There were obvious increase on the concentration of BDNF and TrkB after suction 3 min compared with control(P 0.05),and the concentration of BDNF and TrkB reached peak at postoperative 7 d,decreased at postoperative 10 d,returned to normal level at postoperative 14 d.Compared with experimental control,there were statistical significance on concentration of BDNF and TrkB at postoperative instant and 7 d in suction 3 min(P 0.05),there were no statistical significance at postoperative 10 d and 14 d(P 0.05).Conclusions The high IOP caused by negative pressure suction during LASIK could result in the change of the concentration of BDNF and TrkB,but it is reversible.The longer the duration,the more obvious the change.Neurotrophic factor being stripped is one of the mechanism of RGCs apoptosis." @default.
- W2388055878 created "2016-06-24" @default.
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- W2388055878 date "2012-01-01" @default.
- W2388055878 modified "2023-09-26" @default.
- W2388055878 title "Study on the changes of BDNF /TrkB by transient high iop in rabbit retina" @default.
- W2388055878 hasPublicationYear "2012" @default.
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