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- W2388067490 abstract "Objective To study the relationship between microvessel density (MVD), vascular endothelial growth factors (VEGF) , the expression of p53 and the prognosis of non-small cell lung cancer (NSCLC). Methods A total of 47 specimens of NSCLC were tested by immunohistochemical method (S-P method) for MVD and expressions of VEGF and p53. Results The positive rates of p53 and VEGF were 53.2% (25/47) and 38.3% (18/47). The 3-year survival rates of patients with positive expressions of VEGF and p53 were 29.4% and 38.5%, which were significantly lower than those who negatively expressed VEGF and p53. The 3-year survival rate was significantly lower in MVD-high patients than those with MVD-low patients (38.1% vs 73.1%, P0.05). Conclusions p53 gene and VEGF might play an important role in promoting tumor angiogenesis. These findings support that the higher MVD is related to lower 3-year survival rate, and metastasis is more likely to occur. The positive expressions of p53 and VEGF indicate higher index of MVD and poor prognosis in NSCLC." @default.
- W2388067490 created "2016-06-24" @default.
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- W2388067490 date "2007-01-01" @default.
- W2388067490 modified "2023-09-23" @default.
- W2388067490 title "Relationship Between Microvessel Density, Vascular Endothelial Growth Factors, p53 Expression and Prognosis of Non-small Cell Lung Cancer" @default.
- W2388067490 hasPublicationYear "2007" @default.
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