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- W2388088288 abstract "Objective To establish the model of in vitro differentiation of mouse embryonic stem (ES) cell into cardiomyocytes. Methods ES cells were induced to differentiate into spontaneously contracting cardiomyocytes by using hanging drop culture technique. The expression of the four muscle isoactins was examined in embryoid bodies by RT-PCR. Results The spontaneously contracting cardiomyocytes were observed in embryoid bodies and further differentiated ES cells. α-vascular actin, γ-enteric actin, α-cardiac actin and α-skeletal actin were expressed in these embryoid bodies. Conclusion The establishment of the in vitro differentiation of mouse ES cells into cardiomyocytes provides a system in which genes that directly or indirectly affect the cardiac myogenesis could be studied and will benefit to the application of cardiomyocytes derived from ES cells in clinical therapy." @default.
- W2388088288 created "2016-06-24" @default.
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- W2388088288 date "2001-01-01" @default.
- W2388088288 modified "2023-09-23" @default.
- W2388088288 title "In vitro differentiation of mouse embryonic stem cells into cardiomyocytes" @default.
- W2388088288 hasPublicationYear "2001" @default.
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