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- W2388089849 abstract "Objective To investigate the chromosomal abnormalities and fusion genes of childhood acute myeloid leukemia(AML).Methods AML1-ETO fusion gene derived form t(8;21) and PML-RARα fusion gene derived form t(15;17) were detected with reverse transcription multiplex nested polymerase chain reaction technique(RT-multiplex nested PCR),and MLL fusion gene with LSI-FISH technique.Results Of 155 cases,101 patients(65.2%) had cytogenetic abnormalities.The incidences of cytogenetic abnormalities in FAB subtypes were M577.3%,M365.9%,M263.9%,M462.5%,M660%,and M142.9%.The most frequent abnormality of chromosome number was pesudodipiloid(59 cases,58.4%),the most frequent abnormality of chromosome structure was t(8;21)(31 cases,32.7%) and t(15;17) was the second frequent aberration(27 cases,26.7%).The abnormality of chromosome 11 was found in 10 cases(9.9%),which was associated with FAB subtypes M2,M3 and M5.Dormant and variance translocations were found when applying RT-PCR technique to detect AML1-ETO fusion gene and PML-RARα fusion gene, MLL fusion gene was detected with LSI-FISH probe in 3 of 11 AML patients.Conclusion Chromosome analysis and detection of fusion genes are helpful in the diagnosis of AML and the differentiation diagnosis of AML subtype." @default.
- W2388089849 created "2016-06-24" @default.
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- W2388089849 date "2007-01-01" @default.
- W2388089849 modified "2023-09-23" @default.
- W2388089849 title "Classical and molecular cytogenetic abnormalities of childhood acute myeloid leukemia" @default.
- W2388089849 hasPublicationYear "2007" @default.
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