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- W2388101233 abstract "Objective To evaluate the efficacy and safety of adefovir dipivoxil(ADV) in the treatment of hepatitis B cirrhosis. Methods A total of 78 patients with hepatitis B cirrhosis were randomized into an ADV group or control group,and there were 42 patients in the ADV group and 36 patients in the control group.The patients in the control group received ordinary liver protective drugs while the patients in the ADV group received additional 10 mg of ADV once a day during 12 months.ALT,AST and HBV-DNA were assayed,and Child-Pugh scores were evaluated at the beginning and the end of the test,respectively.Results At the end of the test,the clearance rates of HBVDNA were 52.38%(22/42) and 23.08%(6/26) in the ADV group and control group,respectively,and there was a significant difference,P0.01.The clearance rates of HBeAg were 16.67%(7/42) and 2.78%(1/36) in the ADV group and control group,respectively,and there was a significant difference,P0.05.The average Child-Pugh scores between the ADV group and control group had a significant difference,P0.01.There were no obvious side effects in the ADV group.Conclusions Adefovir dipivoxil can reduce serum HBVDNA levels significantly,and normalize the levels of ALT and AST,and is of safety." @default.
- W2388101233 created "2016-06-24" @default.
- W2388101233 creator A5087027709 @default.
- W2388101233 date "2009-01-01" @default.
- W2388101233 modified "2023-09-26" @default.
- W2388101233 title "Clinical analysis of adefovir dipivoxil in treatment of hepatitis B cirrhosis" @default.
- W2388101233 hasPublicationYear "2009" @default.
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