Matches in SemOpenAlex for { <https://semopenalex.org/work/W2388123336> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2388123336 abstract "Objective To explore the secretion law of high mobility group box 1 (HMGB1)in rat pancreatic acinar cells induced by trypsin activation peptide (TAP)and release of HMGB1 affected by ethyl pyruvate (EP).Methods The experiment was performed in 12 SD rats.The pancreatic acinar cells of rats were taken out and then separated into three groups:control group,TAP group,and EP group.TAP was added into TAP group and EP group (keep TAP at a final concentration of 3 nmol/L),respectively,but EP was added into EP group only(keep EP at a final concentration of 28 mmol/L).The expressions of HMGB1 mRNA and protein were detected by using real-time quantitative reverse transcription polymerase chain reaction (RT-PCR)or Western blot at 3 h,6 h,12 h,and 24 h time point,respectively.The relationship between HMGB1 and TAP action time was explored by rank correlation.Results Compared with control group,the expressions of HMGB1 mRNA and protein were increased with prolongation of the TAP action in TAP group and EP group (P0.05).Compared with TAP group,the expressions of HMGB1 mRNA and protein were decreased in EP group (P0.05).The expressions of HMGB1 mRNA and protein were increased with prolongation of the TAP action (P0.05),and were highest at 12 h time point (P0.01)in TAP group.There were positive correlation between the expressions of HMGB1 mRNA and protein and TAP action time (rs=0.971,P0.01;rs=0.966,P0.01). Conclusions TAP can induce the release of HMGB1 in pancreatic acinar cells.There is positive relationship between TAP in early stage and HMGB1 in later period of acute pancreatitis.EP can inhibit the release of HMGB1." @default.
- W2388123336 created "2016-06-24" @default.
- W2388123336 creator A5003799076 @default.
- W2388123336 date "2012-01-01" @default.
- W2388123336 modified "2023-09-24" @default.
- W2388123336 title "Research of TAP Induction The Pancreatic Acinar Cells to Release HMGB1 in Rat" @default.
- W2388123336 hasPublicationYear "2012" @default.
- W2388123336 type Work @default.
- W2388123336 sameAs 2388123336 @default.
- W2388123336 citedByCount "0" @default.
- W2388123336 crossrefType "journal-article" @default.
- W2388123336 hasAuthorship W2388123336A5003799076 @default.
- W2388123336 hasConcept C104317684 @default.
- W2388123336 hasConcept C105580179 @default.
- W2388123336 hasConcept C126322002 @default.
- W2388123336 hasConcept C127413603 @default.
- W2388123336 hasConcept C134018914 @default.
- W2388123336 hasConcept C153911025 @default.
- W2388123336 hasConcept C170493617 @default.
- W2388123336 hasConcept C17538187 @default.
- W2388123336 hasConcept C185592680 @default.
- W2388123336 hasConcept C2780545709 @default.
- W2388123336 hasConcept C55493867 @default.
- W2388123336 hasConcept C71924100 @default.
- W2388123336 hasConcept C86803240 @default.
- W2388123336 hasConcept C87717796 @default.
- W2388123336 hasConceptScore W2388123336C104317684 @default.
- W2388123336 hasConceptScore W2388123336C105580179 @default.
- W2388123336 hasConceptScore W2388123336C126322002 @default.
- W2388123336 hasConceptScore W2388123336C127413603 @default.
- W2388123336 hasConceptScore W2388123336C134018914 @default.
- W2388123336 hasConceptScore W2388123336C153911025 @default.
- W2388123336 hasConceptScore W2388123336C170493617 @default.
- W2388123336 hasConceptScore W2388123336C17538187 @default.
- W2388123336 hasConceptScore W2388123336C185592680 @default.
- W2388123336 hasConceptScore W2388123336C2780545709 @default.
- W2388123336 hasConceptScore W2388123336C55493867 @default.
- W2388123336 hasConceptScore W2388123336C71924100 @default.
- W2388123336 hasConceptScore W2388123336C86803240 @default.
- W2388123336 hasConceptScore W2388123336C87717796 @default.
- W2388123336 hasLocation W23881233361 @default.
- W2388123336 hasOpenAccess W2388123336 @default.
- W2388123336 hasPrimaryLocation W23881233361 @default.
- W2388123336 hasRelatedWork W2005360552 @default.
- W2388123336 hasRelatedWork W2113561204 @default.
- W2388123336 hasRelatedWork W2353329698 @default.
- W2388123336 hasRelatedWork W2363503276 @default.
- W2388123336 hasRelatedWork W2368631090 @default.
- W2388123336 hasRelatedWork W2371786085 @default.
- W2388123336 hasRelatedWork W2373705192 @default.
- W2388123336 hasRelatedWork W2377830872 @default.
- W2388123336 hasRelatedWork W2383921797 @default.
- W2388123336 hasRelatedWork W2390175465 @default.
- W2388123336 hasRelatedWork W2396942129 @default.
- W2388123336 hasRelatedWork W2431847955 @default.
- W2388123336 hasRelatedWork W2441852297 @default.
- W2388123336 hasRelatedWork W3028875018 @default.
- W2388123336 hasRelatedWork W3029771666 @default.
- W2388123336 hasRelatedWork W3030283438 @default.
- W2388123336 hasRelatedWork W3031186888 @default.
- W2388123336 hasRelatedWork W3032752702 @default.
- W2388123336 hasRelatedWork W3147351929 @default.
- W2388123336 hasRelatedWork W3032173227 @default.
- W2388123336 isParatext "false" @default.
- W2388123336 isRetracted "false" @default.
- W2388123336 magId "2388123336" @default.
- W2388123336 workType "article" @default.