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- W2388130494 abstract "AIM: To investigate the effects of 18-α isomer of glycyrrhizin(magnesium isoglycyrrhizinate,MI) in protecting human hepatocytes(L-02) injured by D-galactosamine(D-GalN) and carbon tetrachloride(CCl4),and research MI in protecting human hepatocytes deeply.METHODS: The cultured L-02 were pre-treated MI,respectively,for protecting these cells from the injury made with CCl4 or D-GalN.Then,the final product of nitrogen(NOx),and the cellular mitochondrial membrane potentials were measured.All the values above were analyzed to research the protective effects of the MI.RESULTS:At the concentration of 1 mg/mL,the MI could improve the survival rate of cells,and significantly reduced NOx releasing from the D-GaLN or CCl4 injured cells(P0.05),and could increase the decreased cell mitochondrial membrane potential caused by D-GalN.CONCLUSION: At the concentration of 1 mg/mL,the MI have protective effects on the D-GalN or CCl4 injured human hepatocytes.The mechanism of these protective effects may be related to the inhibition of NOx release and related to the improvement of the cellular mitochondrial membrane potentia." @default.
- W2388130494 created "2016-06-24" @default.
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- W2388130494 date "2011-01-01" @default.
- W2388130494 modified "2023-09-25" @default.
- W2388130494 title "Protective effect of 18-α isomer of glycyrrhizin on human hepatocytes injured by D-galactosamine and carbon tetrachloride" @default.
- W2388130494 hasPublicationYear "2011" @default.
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