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- W2388133585 abstract "Objective:To investigate the mechanism of the inhibitory effect of melanogenesis of 4 traditional Chinese herbs:Galla chinensis,Radix clematidis,Radix ophiopogonis and Folium perillae,which could decrease the melanin synthesis of melan-a melanocyte.Methods:Extracts of the above four herbs were added to the culture of melan-a respectively.Tyrosinase activity was measured by L-dopa staining.The protein and gene expression level of all melanin synthesis related enzymes(tyrosinase,TRP-1,TRP-2)were tested by Western blot and quantitative real-time RT-PCR,respectively.Results:All the 4 herbs could inhibit the tyrosinase activity of the cultured cells to a certain degree.Galla Chinensis and Radix clematidis could inhibit protein expression and decrease gene expression of Tyr,TRP-1 and TRP-2 compared with the control.Radix ophiopogonis,Folium perillae could decrease the tyrosinase or tyrosinase related proteins but had no effect on the gene expression.Conclusions:Galla chinensis,Radix clematidis may decrease the melanin synthesis by inhibiting Tyr,TRP-1,TRP-2 gene transcription,protein expression and tyrosinase activity of melanocytes.Radix ophiopogonis and Folium perillae may inhibit melanogenesis targeting on the tyrosinase and its related proteins." @default.
- W2388133585 created "2016-06-24" @default.
- W2388133585 creator A5081307254 @default.
- W2388133585 date "2006-01-01" @default.
- W2388133585 modified "2023-09-26" @default.
- W2388133585 title "The mechanism of inhibition of melanogenesis by extracts from traditional Chinese herbs" @default.
- W2388133585 hasPublicationYear "2006" @default.
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