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- W2388139502 abstract "Objective To study the effect of simavastatin on th e osteoblast-MC3T3-E1 proliferation from the levels of cell, protein and gene. Method Five test groups included simavastatin groups (10~ -6 ,10~ -7 ,10~ -8 , 10~ -9 mol/L) and vehil control group. Under cel l culcure with serum, cell growth curves for 8 days was drawn; Under cell culcur e without serum, cell count, MTT test, DNA content and protein quantity within 2 4 hs,48 hs and 72 hs were tested. Result There are no significa nt differences between simvastin groups and control group in growth curves, cell count, MTT test and DNA content. Protein content of 10~ -6 M simvastatin gro up was significantly higher in the 48th hours of cell culture without serum,comp ared with control group(P0.05). Conclusion Simvastatin increased the protein content of MC3T3-E1, but didn't affect the cell prolifer ation." @default.
- W2388139502 created "2016-06-24" @default.
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- W2388139502 date "2008-01-01" @default.
- W2388139502 modified "2023-09-23" @default.
- W2388139502 title "The effect of simavastatin on the osteoblast-MC3T3-E1 proliferation" @default.
- W2388139502 hasPublicationYear "2008" @default.
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