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- W2388141036 abstract "Objective To investigate the effect of MnCl_2(0,150,300μmol·L~(-1))on the antitumor activity of human peripheral blood dendritic cells(DC).Methods Factorial design and orthogonal design were adopted to analysis the effect of MnCl_2(0,150,300μmol·L~(-1)),DC(2×10~3,1×10~4,2×10~4ml~(-1)),E/T(5∶1,10∶1,20∶1)on the antitumor activity of DC;flow cytometry was applied to examine the expression of HLA-DR on the groups of MnCl_2-stimulated DC and the non-MnCl_2stimulated DC.The effect of the best stimulated-DC by the MnCl_2(300μmol·L~(-1))on the cytotoxicity of T cells in SCID mice attacked by hepatic tumor cells(Huh_7)was studied.Results These three factors all had a remarkable effect on the antitumor activity of DC.Both the expression of HLA-DR and the positive percentage of HLA-DR of MnCl_2-stimulated DC were much higher than that of non-MnCl_2-stimulated DC.The occurrence rate and the general volume of tumor in the SCID group injected with MnCl_2-stimulated DC were remarkably less than that of the other group injected with non-MnCl_2-stimulated DC.Conclusion MnCl_2 can remarkably enhance the expression and positive percentage of HLA-DR in DC in vitro.MnCl_2-stimulated DC can remarkably augment the cytotoxicity of T cells and remarkably suppress the growth of tumor(Huh_7) in SCID." @default.
- W2388141036 created "2016-06-24" @default.
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- W2388141036 date "2006-01-01" @default.
- W2388141036 modified "2023-09-25" @default.
- W2388141036 title "Study on the antitumor activity of T cells regulated by the MnCl_2-stimulated DC" @default.
- W2388141036 hasPublicationYear "2006" @default.
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