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- W2388141381 abstract "OBJECTIVE:To investigate the effects of an antisense oligodexynucleotide which targets to low free energy region of Bcl-xl mRNA on anti-expression of Bcl-xl.METHODS:The low free energy region of Bcl-xl mRNA was analysed by software and an ASODN,which targeted to the low free energy region of Bcl-xl mRNA and named As587,was synthesized.As587was transfacted into breast cell line MCF-7 expressing Bcl-xl protein in high level.Three groups were established:blank,antisense(As587)and scramble(Sc587).After 72 h of the transfection,the cell proliferation,Bcl-xl gene and protein expressions were observed respectively.RESULTS:In the As587 and Sc587 groups,The cell inhibition rates were significantly different(P0.01),Bcl-xl/β-actin ratios were 0.39 and 0.79(P0.05),and the Bcl-xl protein decreased in the As587 group(P0.01).CONCLUSION:It's a reliable method to use computer aided design during the application of antisense oligonucleotides,and As587 can suppress the expression of Bcl-xl in vitro." @default.
- W2388141381 created "2016-06-24" @default.
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- W2388141381 date "2008-01-01" @default.
- W2388141381 modified "2023-09-24" @default.
- W2388141381 title "Effect of an antisense oligodeoxynucleotide that targets to low free energy region of Bcl-xl mRNA" @default.
- W2388141381 hasPublicationYear "2008" @default.
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