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• W2388150489 abstract "Objective To observe the cerebral changes and the serum differential protein expression pattern in mice with normobaric anoxic injury, and to find biomarker protein in normobaric anoxic injury. Methods Sixty female Kunming mice were randomly divided into normal control group and normobaric anoxic injury groups. The established normobaric anoxic mice models were divided into 1-week, 2-week, and 3-week groups according to the duration of anoxia. The activity of superoxide dismutase (SOD) and content of malondialdehyde (MDA) in serum and brain were examined. The changes of serum protein expression pattern were monitored with weak cationic exchanger (WCX-2) chips by surface-enhanced laser desorption ionization-time of flight-mass spectrometry. Results Serum SOD activity gradually decreased after normobaric anoxia, there were significant differences in 3-week group compared with normal control group (P 0.01). In comparison with normal control group and anoxia 1-week group, serum MDA content increased significantly in 2-week group (P 0.01, for all). Compared with normal control group, there were no significant differences in brain tissue SOD activity in each group after normobaric anoxia (P 0.05, for all). Brain tissue MDA content in anoxia 2-week group and 3-week group were significantly higher than that in normal control group (P 0.01, for all). The spectrometric analysis of WCX-2 chips showed that the relative intensity of 5 protein peaks with relative molecular weight 3 500, 3 578, 3 706, 3 516 and 4 130 from the 342 serum protein peaks in protein chips increased after anoxic injury. The differences between normobaric anoxia groups and normal control group were significant (P 0.05). Seventy-three serum protein peaks in normobaric anoxia groups were not detected in normal control group. Thirty protein peaks presented within 2 weeks and forty-eight presented after 2 weeks of anoxia in seventy-eight protein peaks. Conclusion Normobaric anoxia may cause cerebral injury in mice and induce changes of oxygen free radical-related enzyme activity in serum and brain tissue. Normobaric anoxia can decrease serum SOD activity and increase serum and cerebral MDA content, and may alter serum protein expression pattern. The results suggest that part of the serum protein may be the products of blood cells gene expression induced by normobaric anoxia injury. Different proteins detected in serum and new occurrence of protein after anoxia may be the biomarkers of cerebral injury." @default.
• W2388150489 created "2016-06-24" @default.
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• W2388150489 date "2007-01-01" @default.
• W2388150489 modified "2023-09-23" @default.
• W2388150489 title "Changes and significance of serum protein expression pattern in mice with cerebral normobaric anoxic injury" @default.
• W2388150489 hasPublicationYear "2007" @default.
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