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- W2388155280 abstract "To investigate comparatively the different responses of T cell subsets induced by dendritic cell(DC)fused respectively with three different concentrations of A.lumbricoides and A.suumantigens(Ag),the levels of the expression of DC surface moleculars,Th1/Th2cytokines and Foxp3mRNA in different MLR groups,which were antigen-loaded DC co-cultured with C57BL/6mouse-derived splenic lymphocytes at the effect-target ratio of 1∶25,were detected respectively by flow cytometry(FCM),ELISA and real-time PCR.And the DCs were isolated from bone marrow cells cultured with granulocyte/ macrophage colony-stimulating factor(GM-CSF)and IL-4 in vitro.The FCM results showed that DCs isolated from bone marrow cells were with high expression of kinds of surface molecules(CD86,85.5%;CD83 38.24%;CD80,94%).CD80and CD83declined after being cultured with ascaris extract for 2days and that of the groups fused separately with Ag of A.lumbricoides and A.suum was respectively higher and lower than the control group.ELISA showed the level of expression of TNF-α in each period of each experimental group was lower than the control group(P0.05);IL-10in each group increased over time,and the groups with ascaris antigen were higher than groups with same concentration of A.suumantigen(P0.05)in each time except the time point of 24hours.The qPCR results showed that the levels of the groups with A.lumbricoides Ag were declined over time but significantly higher than the control groups and the groups with A.suum Ag in different time points(P0.05).The differences between the groups with A.suum Ag and the control groups were not statistically significant(P0.05).In conclusion,DC fused with the Ag of A.lumbricoides promoted a stronger Th2type response and the expression of Foxp3mRNAin vitro." @default.
- W2388155280 created "2016-06-24" @default.
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- W2388155280 date "2013-01-01" @default.
- W2388155280 modified "2023-09-28" @default.
- W2388155280 title "Comparative analysis of T cell subsets response induced by DC fused with Ag of Ascaris lumbricoides and Ascaris suum" @default.
- W2388155280 hasPublicationYear "2013" @default.
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