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- W2388202051 abstract "Objective:To predict the secondary structure and B-cell epitopes of heat shock protein 60 of Chlamydia trachomatis,and further analyse the pathogenic significance in the human autoimmune disease associated with Chlamydia trachomatis.Methods:The amino acid sequence of HSP60 from CT standard strain(E/UW-5/Cx) was selected,and the secondary structure was predicted with SOPMA,GOR,nnPredict and HNN.Combining comprehensive analysis of transmembrane domain,hydrophilicity profile,surface probability,antigenicity index,polarity and average flexibility,B-cell predominant epitopes of CHSP60 was further predicted.Predominant HSP60 epitopes with the amino acid sequence was compared with the homo HSP60 amino acid sequence.Results:Using the four methods mentioned-above,prediction of the secondary structure of CHSP60 indicated that random coils were the main structural type of the flexible region in secondary structure.The B-cell predominant epitopes were probably in the regions of 79～85,135～140,433～440,526～532 and the regions 135～140,433～440 and 526～532 have high homology with the regions 159～164,457～464 and 549～556 of homo HSP60.Conclusion:Within the possible advantages of B cell epitopes of CHSP60,the regions of 135～ 140,433～440 and 526～532 may be associated with human autoimmune diseases." @default.
- W2388202051 created "2016-06-24" @default.
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- W2388202051 date "2010-01-01" @default.
- W2388202051 modified "2023-09-23" @default.
- W2388202051 title "Prediction and analysis of B-cell epitopes of HSP60 of Chlamydia trachomatis" @default.
- W2388202051 hasPublicationYear "2010" @default.
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