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- W2388217445 abstract "Objective:To assess the clinical efficacy of interferon α 2a combined with oxymatrine in the treatment of chronic hepatitis B and in the prevention of hepatic cirrhosis. Methods: 98 patients with chronic hepatitis B were randomly allocated into two groups. 51patients in treatment group were given interferon α-2a 5×10 6?u/d im×15?d, then changed to 5×10 6?u/d im qod up to 6 months; combined with kushensu 400 mg im qod for three months. 47 patients in control group were given the same dose of interferonα 2a as above only. After completion of therapy, liver function tests, markers of hepatitis B virus and liver fibrosis of the two groups of patients were compared. Results: In therapeutic group, serum ALT decrease to normal range in 82.3% of the patients which were significantly different from that of control group ( χ 2=4.310, P 0.05). HbeAg turned to negative in 54.9% of patients in treatment group compared with 34% in control group; HBV DNA turned to negative in 58.8% and 40.4% of patients in the two groups respectively. Levels of serum hyaluronidase(HA), pro collegen type Ⅲ(PCⅢ) and collegen type Ⅳ(Ⅳ C) were significantly different between the two groups( P 0.05). Conclusions: Interferon α 2a combined with oxymatrine may be able to inhibit HBV replication, improve liver function and prevent hepatic fibrosis. It is suggested to be further evaluated in the treatment of patients with chronic hepatitis B." @default.
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- W2388217445 date "2001-01-01" @default.
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- W2388217445 title "Clinical effect of interferon α-2a combined with injectable oxymatrine in the treatment of chronic viral hepatitis B" @default.
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