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- W2388223372 abstract "Objective To analyse insulin resistance,islet β-cell function and related metabolic indexes in the subjects with impaired glucose tolerance.Methods According to the results of oral glucose tolerance test(OGTT),243 subjects were divided into the impaired glucose tolerance group(IGT group,108 cases) and normal glucose tolerance group(NGT group,135 cases).Fasting insulin(FINS) and insulin 2 hours after taking glucose(2hINS),fasting triglyceride(TG),cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) and free fatty acids were measured.The insulin resistance index(HOMA-IR),insulin secretion index(HOMA-β) and glucose desposition index(DI) were calculated.Results ①HOMA-IR level was significantly higher in IGT group than that of NGT group(0.56±0.25 vs 0.40±0.20,P0.01);②DI level was significantly lower in IGT group than that of NGT group(1.66±0.16 vs 2.66±0.21,P0.01);③TG,FFA,FINS and 2 hINS were higher in IGT group than in NGT group(P0.01),and HDL-C was lower than that of NGT group(P0.01);TC,LDL-C,HOMA-β had no significant difference between IGT group and NGT group(P0.05).Conclusion Insulin resistance and hyperinsulinemia are the main characteristics in the subjects with impaired glucose tolerance,and the lipidic toxicity plays an important role in this progress." @default.
- W2388223372 created "2016-06-24" @default.
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- W2388223372 date "2007-01-01" @default.
- W2388223372 modified "2023-09-23" @default.
- W2388223372 title "Changes of insulin resistance,islet β-cell function and related metabolic indexes in subjects with impaired glucose tolerance" @default.
- W2388223372 hasPublicationYear "2007" @default.
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