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- W2388237454 abstract "In the present study,dominant B and Th cell epitopes of MBA were screened by using bioinformatics methods.The secondary structure of the MBA of Uu serotype 3 and 14 was predicted by the methods of GOR4 and HNN.Combined with surface properties of transmembrane domain,hydrophilicity,polarity,average flexibility,surface probability,and antigenicity index,the dominant B cell epitopes of MBA were predicted.At the same time,MHC-II restricted Th epitopes were also predicted.Data indicated that dominant B and Th cell epitopes of MBA were highly homological between Uuserotype 3and14.The sequences rich of B and TH epitopes located in the portion of 31-51,55-75,97-115,and 154-168 amino acid.Four sequences of MBAaa31-51(F1),MBAaa 55-75(F2),MBAaa 97-115(F3),and MBAaa 154-168(F4)rich of B and TH epitopes were selected to be the MBA multi-epitope peptides.BALB/c mice were hypodermically inoculated with selected multi-epitope peptides and their immunogenicity was further evaluated.Data indicated four multi-epitope peptides had strongly immunogenicity and induced specific antibodies significantly higher than PBS group(P0.01).The OD490values in F1,F2,F3,F4 and PBS control were 0.28±0.024,0.29±0.059,0.37±0.058,0.15±0.011 and 0.04±0.008,respectively.These data provides an important basis for the preparation of monoclonal antibodies of MBA and the design of epitope-based Uu vaccines." @default.
- W2388237454 created "2016-06-24" @default.
- W2388237454 creator A5032795695 @default.
- W2388237454 date "2013-01-01" @default.
- W2388237454 modified "2023-09-23" @default.
- W2388237454 title "Prediction of the B cell epitopes for MBA of Ureaplasma urealyticumserotype 3 and serotype 14" @default.
- W2388237454 hasPublicationYear "2013" @default.
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