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- W2388285394 abstract "Apoptosis is the major mechanism by which multicellular organisms clear superfluous,infected,damaged or potentially dangerous cells.The roles of proteolytic enzymes in the regulation of apoptosis were major research topics.Most of the studies were focused on the role and regulation of caspases,which may be indispensable for the typical apoptotic pathway.In recent years,there has been a growing body of evidence to suggest that,in addition to caspases,other proteases,such as cathepsins,may also be involved in apoptosis.Lysosomal cathepsins,in particular cathespin B(CTSB),have been reported to activate caspase-dependent and-independent pathways of cell death. The purpose of this study was to investigate the mechanism of apoptosis in human prostate cancer PC-3 cells.It was showed that both cathepsin B and caspases participated in TNFα-induced apoptosis in PC-3 cells.Cell death induced by TNFα was suppressed by the pretreatment with inhibitors of mitochondria permeability transition and lysosomal cathepsins.Copreincubation with cathepsin B specific inhibitor CA074Me and pan-caspases inhibitor z-VAD-fmk prevented PC-3 cell apoptosis more efficiently than CA074Me or z-VAD-fmk did separately.In addition,inhibition of cathepsin B activity profoundly protected PC-3 cells against D-sphingosine-induced death.These results demonstrate that TNFα-induced apoptosis in PC-3 cells is both cathepsin B-and caspases-dependent,and cathepsin B plays a key role in PC-3 cell death induced by D-sphingosine." @default.
- W2388285394 created "2016-06-24" @default.
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- W2388285394 date "2012-01-01" @default.
- W2388285394 modified "2023-09-26" @default.
- W2388285394 title "Apoptosis of Human Prostate Cancer PC-3 Cells is Mediated by Lysosomal Cathepsin B" @default.
- W2388285394 hasPublicationYear "2012" @default.
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