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- W2388286706 abstract "Objective To investigate the effect on proliferation inhibition of human nasopharyngeal carcinoma (NPC) cells by Lipofectin mediated bcl xL antisense oligodeoxynucleotide (ASODN).Methods ASODN and sequence control ODN (SCODN) were synthesized and combined to Lipofectin (Lip) to prepare Lip+oligonucleotides(ODN) complexes. After exposure to Lip+ODN complexes for 36 hours and continuous incubation in complete medium for another 24 hours, the growth inhibition of human NPC cell lines CNE 1 and CNE 2Z was measured by MTT assay and flow cytometry(FCM) was used to observe apoptotic changes in ASODN treated cells.Results Treatment of CNE 1, CNE 2Z cells with ASODN at a concentration of 400 nmol/L for 36 hours significantly decreased the viability. The effect of inhibition of cells was enhanced with increasing concentration and exposure time. This resulted in the induction of apoptosis characterized by apoptotic peak. Cells incubated with the sequence control ODN(SCODN) or Lipofectin alone had no similar effect. Conclusions Lipofectin mediated bcl xL ASODN could efficiently inhibit cell growth of NPC cell lines CNE 1 and CNE 2Z.ASODN may be used in the gene therapy for human nasopharyngeal carcinoma." @default.
- W2388286706 created "2016-06-24" @default.
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- W2388286706 date "2003-01-01" @default.
- W2388286706 modified "2023-09-28" @default.
- W2388286706 title "Study on proliferation inhibition of nasopharyngeal carcinoma cells by Lipofecton-mediated bcl-xL antisense oligodeoxynucleotides" @default.
- W2388286706 hasPublicationYear "2003" @default.
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