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- W2388290990 abstract "Objective To study the impact of local mild hypothermia on serum serum matrix metalloproteinase(MMP-9) and cell fibronectin(c-Fn) in patients with acute intracerebral hemorrage.Methods Eighty patients with acute cerebral hemorrage were randomly divided into local mild hypothermia group(40 cases) and routine therapy group(40 cases).Meanwhile,there was a control group of twenty-three healthy cases.Conventional drugs were given to routine therapy group while the mild hypothermia group was given local mild hypothermia treatment but for conventional therapy.Serum levels of MMP-9 and c-Fn in patients were determined dynamically on the 1st,3rd and 7th day after paroxysm.Results On the 1st day after paroxysm,the serum levels of MMP-9 and c-Fn in patients with intracerebral hemorrhage were apparently higher than the normal controls(P0.01).On the 3rd day,the levels of MMP-9 and c-Fn were significantly decreased in local mild hypothermia group in comparison with routine therapy group(P0.05).On the 7th day after paroxysm,the levels of MMP-9 and c-Fn in local mild hypothermia group were still significantly lower than that of routine therapy group(P0.05).Conclusion The local mild hypothermia therapy can not only dramatically reduce the serum levels of MMP-9 and c-Fn but also inhibit inflammatory reaction so as to protect neurological function in patients with cerebral hemorrhage." @default.
- W2388290990 created "2016-06-24" @default.
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- W2388290990 date "2011-01-01" @default.
- W2388290990 modified "2023-09-28" @default.
- W2388290990 title "The impact of local mild hypothermia on serum levels of serum matrix metalloproteinase (MMP-9) and cell fibronectin (c-Fn) in patients with intracerebral hemorrhage" @default.
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