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- W2388328918 abstract "OBJECTIVE To study inflammatory effect of TNFα on the cultured human MC and the inhibitory role of Dexamethesone(DXM).METHODS Human MC was cultured by the routine method in vitro.MC proliferation was measured by 3 H-TdR incorperation.IL 1 and extra cellular matrix (LN?FN)were measured by ELISA.RESULTS TNFα stimulated MC 3 H-TdR incorperation,remarkblely (P0.01).Meanwile,TNFα promoted MC to secrete IL 1?LN and FN (P0.01). DXM inhibited not only the incorperation of MC 3 H-TdR thus blocking the secretion of IL 1, but also blocking the secretion of LN? FN. The inhibiting effect of DXM was shown to be the dose-dependent (P 0.05). CONCLUSION TNFα is one of the stimulating factors of MC proliferation and secretion of IL 1 and FN?LN. DXM can inhibit the proliferation and the secretion of IL 1?LN and FN of MC mediated by TNFα." @default.
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- W2388328918 date "2003-01-01" @default.
- W2388328918 modified "2023-09-27" @default.
- W2388328918 title "DXM inhibited glomerular mesangial cells mediated by TNFα" @default.
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