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- W2388339923 abstract "Objective To explore potential biomarker candidate(s) in stage Ⅱ breast infiltrating ductal carcinoma with negative estrogen receptor (ER-) and to discuss the significance of the identified proteins in tumor invasion and metastasis.Methods Two-dimensional polyacrylamide gel electrophoresis (2-DE) in combination with matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry (MALDI-TOF-MS) and bioinformatics analysis were performed to investigate differential proteins of the infiltrating ductal carcinoma at stage Ⅱand adjacent normal breast tissues from 5 breast cancer patients with negative estrogen receptor.Results The number of the tested protein spots from 5 adjacent normal breast tissues was from 779 to 1 328.The number of the tested protein spots from 5 breast cancer tissues was from 988 to 1 453.The correspondent spots was from 310 to 774. Three differential proteins (S1,S2,S3) from the 2-DE gel images of 5 patients’ cancer tissues and adjacent normal tissues were obtained.Three protein candidates were identified: immunoglobulin lambda chain variable region (S1),collagen alpha-3 (Ⅵ) chain precursor (S2) and S100 calcium binding protein A11 (S3).Proteins S2 and S3 were found to be up-regulated in all 5 cancer tissues (abundance changed more than 2 folds).Conclusion Proteins can be obtained efficiently from tissues under the condition of optimized protocols of tissue 2D-PAGE;Collagen alpha-3 (Ⅵ) and S100 calcium binding protein are likely involved in invasion and metastasis in the stage Ⅱ breast infiltrating ductal carcinoma with negative estrogen receptor." @default.
- W2388339923 created "2016-06-24" @default.
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- W2388339923 date "2009-01-01" @default.
- W2388339923 modified "2023-09-26" @default.
- W2388339923 title "Differential proteomic analysis in stage II breast infiltrating ductal carcinoma tissue with negative estrogen receptor" @default.
- W2388339923 hasPublicationYear "2009" @default.
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