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- W2388341285 abstract "AIM: To investigate the density of mature dendritic cells (DC) in sentinel lymph nodes (SLN) and non-SLN in patients with different levels of metastatic involvement. METHODS: The female breast cancer patients were divided into 3 groups: group A, all lymph nodes without evidence for tumor cells; group B, small tumor deposits in SLN defined as: B1, isolated tumor cells in SLN, non-SLN without evidence of tumor cells; B2, micrometastases in SLN, non-SLN without evidence of tumor cells; group C, macrometastases in SLN, involved or un-involved non-SLN one section of all SLN and non-SLN of these patients was underwent immunohistochemical examination by using the DC-LAMP-antibody for identification of mature dendritic cells. The density of the DC-LAMP~+-cells of each slide was quantified by a Zeiss imaging system enregistering the percentage of the area occupied by DC-LAMP~+-cells. The Wicoxon-test and Mann-Whitney-test were used to compare the mean density of DC-LAMP~+-cells of SLN and non-SLN individually in each group and interindividually between the different groups, respectively. RESULTS: The DC-LAMP~+-cell density increased significantly in the SLN compared to non-SLN patients with tumor free lymph nodes and patients with micrometastases in the SLN (P0.05, P0.01). No significant increase in DC-LAMP~+-cell density between the SLN of the three groups, but a significantly reduced DC-density in non-SLN of patients with micrometastases and isolated tumor cells was observed, compared to the other two groups (P0.05,P0.01). CONCLUSION: The results further underlined the prominent role of the SLN for tumor-lymph node interactions, revealing significant differences between SLN and non-SLN in regard to the density of DC-LAMP~+-cells." @default.
- W2388341285 created "2016-06-24" @default.
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- W2388341285 date "2006-01-01" @default.
- W2388341285 modified "2023-09-25" @default.
- W2388341285 title "DC-LAMP~+ dendritic cells in sentinel and non-sentinel lymph nodes of breast cancer patients with different lymph node metastatic status" @default.
- W2388341285 hasPublicationYear "2006" @default.
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