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- W2388352170 abstract "OBJECTIVE To evaluate the effects of amlodipine on improving prethrombotic state of hypertensive patients.METHODS Amlodipine (5mg) was given to 50 patients,q.d.for 6 weeks. Blood pressure, heart rate and hemostatic molecular markers including thromoxane B 2(TXB 2),6-keto-prostglandin F 1∝ (6-K-PGF 1∝ ),tissuetype plasminogen activator(t-PA)and Its inhibitor(PAI-1)as well as hemorheologic indexes were measured be for and arter amlodipine administration.RESULTS After the treatment, blood pressure was decreased sigmificantly(P0.05);plasma levels of TxB 2,t-PA and PAI-1 level and activity and blood viscosity were also decreased significantly(P0.05).At the same time, the activities of t-PA and 6-K-PGF 1∝ increased(P0.05). Amlodipine had no significant effect on the heart rate of patients.CONCLUSION Amlodipine could lower blood pressure and improve prethrombotic state of hypertensive patients simultaneously." @default.
- W2388352170 created "2016-06-24" @default.
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- W2388352170 date "2005-01-01" @default.
- W2388352170 modified "2023-09-25" @default.
- W2388352170 title "The Effect of Amlodipine on Prethrombotic State in Patients with Hypertension" @default.
- W2388352170 hasPublicationYear "2005" @default.
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