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- W2388393438 abstract "Objective To explore the effect of mammalian target of rapamycin and p70 S6 Kinase on rabbit periodontal remodeling on orthodontic tooth movement. Methods Twelve rabbits (weight 2.0±0.2kg) were divided randomly into groups of 3,5,7 and 14 days with 3 rabbits in each group to establish rabbit models for the study. The appliances were located on the right maxillary in the test group and unfixed appliances on the left in the control group. The animals were killed at each time intervals(3,5,7 and 14 d) respectively. Western blot test was applied to evaluate the expression of mTOR and p70 S6K. Results The expression of mTOR and p70 S6K was observed changing dramatically; the expression of mTOR and p70 S6K in the periodontal tissues with orthodontic treatment was higher than that in the control,up to the peak on the 7th day,and then decreased,with statistical significance compared with the control group(P 0.01). Conclusion mTOR and p70 S6K participate in the tissue remodeling during orthodontic tooth movement and may play a more important role in the process of periodontal remodeling." @default.
- W2388393438 created "2016-06-24" @default.
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- W2388393438 date "2008-01-01" @default.
- W2388393438 modified "2023-09-25" @default.
- W2388393438 title "Effect of Orthodontics on Mammalian Target of Rapamycin and p70 S6 Kinase in Rabbit Periodontal Tissues" @default.
- W2388393438 hasPublicationYear "2008" @default.
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