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- W2388402171 abstract "AIM: To identify the proteins related to aging in the mitochondria of the heart.METHODS: Mitochondria were isolated from the hearts of adult(10-week) and old(12-month) rats(n=3).Total proteins extracted from the mitochondria were applied to the two-dimensional gel electrophoresis.The differentially expressed protein spots evaluated by a software were subjected to in-gel digestion,and analyzed by the matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF-MS).ATP content in the heart was also measured.RESULTS: Eighty-four differentially expressed protein spots were observed,and fifteen of them were analyzed by MALDI-TOF-MS.Four proteins including creatine kinase,peroxiredoxin 2,Tu translation elongation factor and isocitrate dehydrogenase were up-regulated and 11 proteins including succinate dehydrogenase,malate dehydrogenase,aconitate hydratase,NADH dehydrogenase,ATP synthase H~+ transporting,ATP synthase beta chain,heat shock protein 60,glucose-regulated protein 78,prohibitin,Aldehyde dehydrogenase 2 and voltage-dependent anion channel exhibited down-regulation in the aging group compared to the adult one.ATP content in the heart of old rats was significantly reduced as compared to that in adult rats(n=5,P0.01).CONCLUSION: Significant changes in the mitochondrial protein expression in the aging heart were identified by the 2-DE electrophoretogram with high resolution and reproducibility.The functions of these identified proteins need to be further investigated." @default.
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- W2388402171 date "2006-01-01" @default.
- W2388402171 modified "2023-09-23" @default.
- W2388402171 title "Comparative proteomics of myocardial mitochondrial proteins in aging rats" @default.
- W2388402171 hasPublicationYear "2006" @default.
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