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- W2388402502 abstract "Objective To study the influence of hypoxia on hypoxia-inducible factor-1α(HIF-1α) and glycolysis associated protein in esophageal carcinoma TE1.Methods Esophageal cancer TE1 were incubated under normoxic and hypoxic conditions for different time(6,12,24,48 h).Expressions of HIF-1α protein and the associated enzyme in glycolysis(HK-II) were detected by Western blot.Results HIF-1α and HK-II protein were both expressed in normoxic conditions.The expression of HIF-1α and HK-II increased after incubated in hypoxia environment,both reached perk at 12 h(P0.05).Conclusion Hypoxia condition can up-regulate the expression of HIF-1α and HK-II.Joint suppression of HIF-1α and key enzymes in glycolysis could become the potential targets for treatment of esophageal cancer." @default.
- W2388402502 created "2016-06-24" @default.
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- W2388402502 date "2011-01-01" @default.
- W2388402502 modified "2023-09-24" @default.
- W2388402502 title "Influence of hypoxia on hypoxia-inducible factor-1α and Hexokinase-II in esophageal carcinoma" @default.
- W2388402502 hasPublicationYear "2011" @default.
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