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- W2388408489 abstract "Objective To observe serum interleukin-18(IL-18) levels in chronic hepatitis C treated with polyethylene glycol interferon(PEG-INF). Methods Thirty-one patients were treated with PEG-IFN for 24 weeks (subcutaneous injection of 180 ?滋g, once week), and followed 24 weeks. Fifteen health volunteer were taken as control group. Alanine aminotransferase, HCV RNA contents were determined at 0, 12, 24 and 48th week after antiviral treatment. The level of serum IL-18 was determined at 0,4,12 and 24 th week after antiviral treatment. Results The level of IL-18 was closely related with the degree of liver injury(P 0.05), and was much higher in sustained responder than those in part-responders and non-responders at 0 and 4th week after the treatment(P 0.05),and then began to decrease significantly at 12th and 24th week(P 0.05).There was no significance between part-responders and non-responders after the treatment. Conclusion IL-18 may take part in the host immunity against HCV. The patients with high IL-18 level before treatment and at the 4th week have more possibility of obtaining sustained response than patients without it." @default.
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- W2388408489 date "2007-01-01" @default.
- W2388408489 modified "2023-09-28" @default.
- W2388408489 title "Changes of the serum interleukin-18 in chronic hepatitis C treated with polyethylene glycol interferon" @default.
- W2388408489 hasPublicationYear "2007" @default.
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