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- W2388420912 abstract "Objective: To study the alterations of NR1 mRNA expression and its relationship with apoptosis in hippocampus of rats following transient forebrain ischemia. Methods: Rats ischemia (15 min) reperfusion (0.5-7 d) (IR) model was created by four-vessel occlusion. In situ hybridization,TUNEL staining and image analysis system were used. Results: (1)In the CA1 region, the expression of NR1 mRNA increased obviously at IR 2 h and peaked at IR 24 h,then the expression started to decrease until IR 7 d. In the CA3 region, the pattern of NR1 mRNA expression was similar to that in the CA1 region, but the expression changed slightly. In the dentate gyrus, the expression of NR1 mRNA had no significant change during IR 72 h and dropped to the lowest on the IR 7 d. (2)At IR 24 h, the TUNEL positive cells appeared most in the CA1 region. Then they gradually increased and reached peak at IR 72 h. Afterwards,the positive cells started to reduce, but still existed on the IR 7 d. Conclusion: NR1 mRNA expression and cell apoptosis are different in different regions of hippocampus after IR. The unique alterations of NR1 mRNA expression might be responsible for the selective vulnerability and ischemic apoptosis in hippocampus after IR." @default.
- W2388420912 created "2016-06-24" @default.
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- W2388420912 date "2004-01-01" @default.
- W2388420912 modified "2023-09-27" @default.
- W2388420912 title "Expression of NR1 mRNA in rat hippocampus following ischemia and its relationship with apoptosis" @default.
- W2388420912 hasPublicationYear "2004" @default.
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