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- W2388431301 abstract "AIM: To determine whether the vitreous cavity (VC) is capable of supporitng the induction of deviant immune response to retinal soluble (S) antigen and to observe the influence of interleukin -1 (IL -1) on the immunologic properties of the VC.METHODS: Retinal S antigen was inoculated into the anterior chamber (AC) and VC in Wistar rats. Seven days after antigen inoculation, the recipient animals were immunized with S antigen and complete Freund's adjuvant. Delayed- type hypersensitivity (DTH) was then assessed by footpad challenge. To alter systemic immune conditions, IL - 1 was administrated by intraperitoneal injection. RESULTS: Antigen - specitic DTH did not develop in rats in which S antigen was injected into the AC and the VC.In contrast; strong DTH was elicited by S antigen injected into the AC and VC if IL - 1 was administrated systemically for 7 consecutive days after the antigen challenge. CONCLUSION: The VC is capable of supporting immune deviation to soluble antigen by actively suppressing antigen - specitic DTH. Systemic administration of ex ogenous IL - 1 eliminates the capacity of the VC to support immune deviation inducing by soluble antigen injected locally." @default.
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- W2388431301 date "1999-01-01" @default.
- W2388431301 modified "2023-09-23" @default.
- W2388431301 title "Immune deviation elicited by retinal S antigen injected into the vitreous cavity" @default.
- W2388431301 hasPublicationYear "1999" @default.
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