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- W2388435452 abstract "Aim To study the inhibitory effect of all trans retinoic acid(ATRA) on 143B osteosarcoma cells and the possible mechanism.Methods First,the endogenous retinoids nuclear receptor expression in 143B and MG63 osteosarcoma cells were tested,Then cell counting was employed to test the proliferation inhibitory effect of ATRA on 143B cells.Western blot was used to test the caspase-3 level,as well as apoptosis staining,to make sure that ATAR can not only inhibits proliferation but also induces apoptosis in 143B cells.Finally,the luciferase reporter assay was adopt-ed to check the osteogenic transcription factor activity of Runx2,the protein expression of osteopontin and osteocalcin were measured with western blot.Results Different types of retinoids nuclear receptor were detected in 143B and MG63 osteosarcoma cells.ATRA inhibited the proliferation of 143B cells in a concentration-dependent manner,The caspase-3 increased apparently after the cells were treated with ATRA for 12 hour and the apoptosis staining was positive apparently.The transcription activity of Runx2 increased,so did the protein level of osteopontin and osteocalcin.Conclusion ATRA can inhibit the proliferation of 143B osteosarcoma cells and induce the cell apoptosis.These effects may at least result from the osteogenic differentiation of osteosarcoma cells initialized by ATRA via retinoic acid signaling." @default.
- W2388435452 created "2016-06-24" @default.
- W2388435452 creator A5008026933 @default.
- W2388435452 date "2011-01-01" @default.
- W2388435452 modified "2023-09-24" @default.
- W2388435452 title "Effect of ATRA on the growth of 143B osteosarcoma cells" @default.
- W2388435452 hasPublicationYear "2011" @default.
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